Interestingly, mutations leading to presumed haploinsufficiency of GRHL2 cause autosomal-dominant non-syndromic hearing impairment (DNFA28 [MIM: 608641])52, 53, 54 and homozygous missense mutations have been associated with autosomal-recessive ectodermal dysplasia syndrome with hearing loss (ECTDS [MIM: 616029]).55 This evidence concerns the gene GRHL2 and autosomal dominant nonsyndromic hearing loss.