A 4-color flow cytometric T-cell analysis was performed to characterize T-cells upon stimulation of whole blood samples from 17 SLE patients and 17 HCs with the lytic cycle CMV antigen pp52, in order to investigate whether the previously established reduced T-cell response to EBV antigens [18] also applies to the CMV-directed T-cell response. This evidence concerns the gene LSP1 and systemic lupus erythematosus.