In a group of newly diagnosed CML patients, Vezzalini et al. used an RPTPγ antibody (TPγ B9-2) to confirm down-regulation of RPTPγ at diagnosis and demonstrated that following tyrosine kinase inhibitor treatment its expression recovered, together with a return to normal haematopoiesis [76]. Here, PTPRG is linked to chronic myelogenous leukemia, BCR-ABL1 positive.