Knockdown analysis also proved that SET7 only suppresses Tat transactivation of the viral promoter and has on influence on transcriptional activity of methylation-deficient Tat Shan’s study suggested that SET7 can negatively regulate the anti-viral activity toward vesicular stomatitis virus (VSV) and influenza A by methylation at Lys-88 of virus (IAV) infection of Interferon-induced Transmembrane Protein 3 (IFITM3) [44]. This evidence concerns the gene TAT and infection.