In tumours, mainly the intracellular functions of Gal-1 have been linked to pro-tumourigenic process, as Gal-1 can interact with oncogenic H-RAS to promote angiogenesis [11], while Galectin 3 (Gal-3) and K-RAS proteins are found to team up in an unholy alliance in cancer cells. Here, LGALS3 is linked to neoplasm.