Interestingly, amplification of the ASH2L locus in some breast cancers appears to result in ASH2L overexpression, which is positively correlated with increased expression of ERα. This is mediated by GATA3, which binds to an enhancer of the gene encoding ERα and recruits ASH2L and a KMT2 complex [171]. Here, ESR1 is linked to breast carcinoma.