Besides the Wnt signaling cascade, TGF-β signaling intermediates including Sma and Mad-related protein 2 and 4 (SMAD 2,4), Runt-related transcription factor 3 (RUNX3), and Thrombospondin 1 (TSP1) are highly misregulated during CRC [21]. The gene discussed is THBS1; the disease is colorectal carcinoma.