From analysing the expression changes of 18 key genes involved in regulation of cell signal transduction, gene expression, invasion, growth, angiogenesis, apoptosis, and antioxidation, they identified five genes that could be used in the prediction of tumour recurrence in CRC patients: BMI-1 polycomb ring finger oncogene (BMI), Vascular endothelial growth factor A (VEGFA), Ribosomal protein S10 (RPS10), Ets variant 6 (ETV6), and H3 histone, family 3B (H3F3B). Here, H3-3B is linked to colorectal carcinoma.