These models facilitate the identification of germline mutations of the genes involved in DNA mismatch repair (MMR) including MutS protein homolog 2 and 6 (MSH 2,6), MutL protein homolog 1 (MLH1), and PMS1 homolog 2 (PMS2), which all cause MSI in patients with hereditary HNPCC/Lynch syndrome [13]. This evidence concerns the gene MLH1 and hereditary nonpolyposis colon cancer.