SAV1 and adenoma: The transcription factor Yes-associated protein (Yap), which is normally inactivated by Hippo signalling, is required for the formation of adenomas following loss of Apc. In this context, Apc acts as a scaffold for Hippo pathway kinases Salvador (Sav1) and Large tumour suppressor kinase 1 (Lats) to facilitate phosphorylation and subsequent degradation of Yap [121] (Figure 1v).