This activity could be mediated by ERs or GPER1 (G protein-coupled estrogen receptor 1), which was shown to trigger proliferation and migration in laryngeal squamous cell carcinoma (LaSCC) via Interleukin-6(IL-6) and signal transducer and activator of transcription 3 (STAT3) [108]. Here, GPER1 is linked to laryngeal squamous cell carcinoma.