FCGR2B and systemic lupus erythematosus: The importance of the FcγRIIB TM domain is also supported by a rich amount of epidemiological studies showing a strong positive correlation of the FcγRIIB-I232T mutant with SLE disease (Chen et al., 2006; Chu et al., 2004; Clatworthy et al., 2007; Kyogoku et al., 2002a; Kyogoku et al., 2004; Niederer et al., 2010a; Niederer et al., 2010b; Pan et al., 2006; Siriboonrit et al., 2003; Willcocks et al., 2010).