Although epidemiology studies in literature did not find a significant correlation between FcγRIIB-I232T homozygotes with RA (Chen et al., 2008; Kyogoku et al., 2002c; Radstake et al., 2006), it is striking to observe that RA patients carrying homozygous FcγRIIB-T232 would develop severe radiologic joint damage during the first six-year course of the disease (Radstake et al., 2006). This evidence concerns the gene FCGR2B and rheumatoid arthritis.