It is noteworthy that the localization of fibrillar amyloid in healthy elders and in AD does not reflect the patterns of cortical thinning, hypometabolism, or clinical phenotypes; these appear to converge with the localization of tau (Ossenkoppele et al., 2016; Schöll et al., 2016; Xia et al., 2017; Lockhart et al., 2017; Pontecorvo et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.