APP and Alzheimer disease: High levels of amyloid in the putamen were reported also in various cases of preclinical and clinical AD related to PSEN1, PSEN2, and APP mutations (Klunk et al., 2007; Remes et al., 2008; Koivunen et al., 2008; Villemagne et al., 2009; Fleisher et al., 2012; Shi et al., 2015; Rodriguez-Vieitez et al., 2016).