For example, nuclear localization of Bcl-2 and Bcl-xL was observed in various cancer cells including breast cancer, endometrial carcinoma, squamous cell carcinoma, and astrocytoma (Chan et al., 1995; Mosnier et al., 1996; Choi et al., 2016). This evidence concerns the gene BCL2L1 and astrocytoma (excluding glioblastoma).