TM6SF2 and metabolic dysfunction-associated steatotic liver disease: Other SNPs have been identified in the pathogenesis of NAFLD, glucokinase regulatory protein (GCKR) rs126032628, and transmembrane 6 superfamily member 2 (TM6SF2)rs5854292629, and when assessed with PNPLA3 rs6006460, these three SNPs seem to have an additive effect on determining intrahepatic fat content29.