Other SNPs have been identified in the pathogenesis of NAFLD, glucokinase regulatory protein (GCKR) rs126032628, and transmembrane 6 superfamily member 2 (TM6SF2)rs5854292629, and when assessed with PNPLA3 rs6006460, these three SNPs seem to have an additive effect on determining intrahepatic fat content29. Here, GCKR is linked to metabolic dysfunction-associated steatotic liver disease.