TLR4 and sinusitis: Other genes showed weaker changes, although in some cases the change reached statistical significance, namely SOD2 average expression was more than double after treatment among patients with pharyngitis (p = 0.007), TLR4 was one third lower in subjects affected with rhinitis (p = 0.02), and NFKB1 was 20% higher in the subgroup with sinusitis (p = 0.04).