CD19 and hematologic disorder: Building on the knowledge gained with CAR T-cells, a multitude of preclinical studies have tested the efficacy of CAR NK cells against a variety of target antigens for hematological malignancies such as CD19 (167, 169), CD20 (209, 210), CD138 (211), CS1 (111), CD3 (212), CD5 (101), CD123 (213), as well as solid tumors such as HER-2/Erb-2 (109, 214–216), GD2 (114), EpCAM (195), EGFR and mutant EGFRvIII (89), WT1 (217), and ROR-1 (218) to name a few.