Furthermore, four hub genes (degree of interaction > 10) were identified: Sykb, Ccrl2, Sell, and Trem3. We focused on the yellow module, specifically, Sykb because it has emerged as a therapeutic target in autoimmune diseases (38), and we observed an increased expression of SYK mRNA in perilesional skin of BP patients (Figure 1C). This evidence concerns the gene SELL and autoimmune disease.