On the other hand, trypanotolerant animals are able to switch to a protective anti-inflammatory response (induced via IL-10), which is reflected by the occurrence of M2 cells that in concert with IL-10 are able to dampen the pathological effects of the M1 cells, and exhibit an alleviated anemia development [i.e., T. brucei attenuation strategies, phospholipase-C-deficient (PLC−/−) T. brucei and T. congolense model]. Here, IL10 is linked to anemia (phenotype).