Further measurement of anti-ENAs antibodies, including anti-SmB, anti-SmD, anti-SmE, anti-rRNP and anti SAA/Ro antibodies, in mice serum by ELISA also supported that EP1, EP4, EP6, and EP10 increased the levels of autoantibodies related to SLE. This evidence concerns the gene PTGER4 and systemic lupus erythematosus.