This study was aimed to predict B-cell epitopes of EBV EA, MA, LMP-1, LMP-2A related to SLE self-antigens, combine and purify B-cell epitope peptides (EPs) and to investigate their immunogenicity and antigenicity through animal experiments, and further evaluate the association of serum EPs indirect levels with risk and disease severity in SLE patients. The gene discussed is PDLIM7; the disease is systemic lupus erythematosus.