Early antigen protein D (EA), envelope glycoprotein GP340/membrane antigen (MA), LMP-1, and LMP-2A are essential parts of EBV and have been observed to be correlated with SLE susceptibility (6, 31, 32), And our preliminary investigation found that EBV EA, MA, LMP-1, and LMP-2A mRNAs expressions were elevated in PBMCs of SLE patients, and previous reports by our lab disclosed that the B epitopes of LMP-2 presented with good antigenicity and immunogenicity in mice (33, 34). Here, ERVW-1 is linked to systemic lupus erythematosus.