Cross-reactivity of autoantibodies against epitopes on SLE small nuclear ribonucleoprotein-associated protein B (SmB) and SmD with various domains of EBNA-1 has been reported in SLE, and lupus-like autoimmune disease appears in rabbits after immunization by EBNA-1 motif PPPGRRP (27–29). Here, SNRPN is linked to autoimmune disease.