MAPT and argyrophilic grain disease: In other diseases, such as PSP, CBD, AGD, globular glial Tauopathy, and aging-related Tau astrogliopathy, isoforms with 4R Tau are found in the filaments (Table 1) (3), but the presence of 3R Tau-positive neuronal inclusions has also been reported in PSP and CBD (58, 59).