Binge-like DID alcohol consumption in C57BL/6J mice also altered CRF levels and electrophysiological properties of the central amygdala (15), but in contrast to alcohol dependence and msP findings, CRF immunoreactivity increased, presynaptic GABA release was unchanged, and CRF lost the ability to enhance evoked GABAergic currents after DID. Here, CRH is linked to alcohol dependence.