For 20 week-old mice, there is no difference in body weight between TRIM31−/− and WT mice (Figure 2E) the blood glucose value was higher at 30 min (P < 0.001) and 60 min (P < 0.01) after intraperitoneal glucose administration in TRIM31−/− mice, indicating that impaired glucose tolerance was exacerbated in TRIM31−/− mice with aging (Figure 2A). Here, TRIM31 is linked to Impaired glucose tolerance.