Giving that TRIM31 plays a central role in regulating NLRP3 inflammasome activity and NLRP3 inflammasome activation can increase the risks of metabolic diseases, we aimed to determine glucose metabolic health, gut microbiota composition, and inflammatory cytokine levels in TRIM31−/− mice, and further investigate whether or not certain gut microbiota taxon correlates with specific metabolic parameters and inflammation cytokines in TRIM31−/− mice. The gene discussed is NLRP3; the disease is Other metabolic disease.