The A2AR is recognized as mediating major adenosine anti-inflammatory activity (Welihinda and Amento, 2014) and is involved in various metabolic and pathological states including sleep regulation, ischemia-reperfusion injury, inflammation and autoimmune diseases and neurodegenerative disorders (Borea et al., 2016; Sharma et al., 2016; Lazarus et al., 2017; Stockwell et al., 2017). This evidence concerns the gene ADORA2A and autoimmune disease.