NFKB1 and rheumatoid arthritis: Activated p38MAPK could regulate the expressions of MMPs, NF-κB and fibrinous actin (F-actin), etc., which played an important role in the pathogenesis of RA joint swelling, synoviocyte dysplasia, angiogenesis, articular cartilage and bone erosion and progressive destruction (Li et al., 2013; Criado et al., 2014; Wang et al., 2015; Zou et al., 2016).