Consist with our results, previous studies have also demonstrated that Ym-1+, CD206+, or CD163+ macrophages were increased and had the potential effect on liver inflammatory changes in different liver inflammation and fibrosis animal models (Beljaars et al., 2014; Ohtsuki et al., 2015; Svendsen et al., 2017). The gene discussed is CD163; the disease is fibrosis.