However, several studies in the recent past have now suggested the involvement of TRPV1 in mechanical pain hypersensitivity in the context of a number of painful pathologies, such as inflammation, nerve injury, sickle cell disease and primary bone cancers (Ghilardi et al., 2005; McGaraughty et al., 2008; Shinoda et al., 2008; Hillery et al., 2011; Brenneis et al., 2013; Chung et al., 2015). Here, TRPV1 is linked to bone neoplasm.