Initial phenotypic reports of the TRPV1-null mouse appeared to rule out a role for TRPV1 in normal or pathological mechanotransduction (Caterina et al., 2000), but subsequent studies in inflammatory, nerve injury, muscle injury, sickle cell and sarcoma models have all implicated TRPV1 in mechanical hypersensitivity (McGaraughty et al., 2008; Shinoda et al., 2008; Pan et al., 2010; Hillery et al., 2011; Walder et al., 2012; Brenneis et al., 2013; Chung et al., 2015). The gene discussed is TRPV1; the disease is sarcoma.