AKT1 and ischemia: A connection between HIF-1 and mTORC1 has been reported: Isoflurane preconditioning, which reduces neurological deficits, infarct volume, brain edema and apoptosis after ischemia induction, up-regulated HIF-1α expression via Akt/mTOR/p70S6K activation (Yan et al., 2016).