TNFRSF25 and neoplasm: Second and foremost, unlike in tissue culture where cells divide every 20–50 h, in patients, tumor’s doubling times are in the order of tens to hundreds of days.47 Our finding that anti-tubulin drugs induce activation of DR3 by autocrine TL1A raises an interesting possibility that these drugs not only directly stop tumor cells from dividing, but also cause them to undergo apoptosis that might ultimately contribute to the efficacy of those therapies.