To this end, we compared the expression of twelve genes either linked to the induction of innate immunity (STAT1, STAT2, PKR) or IFN effector genes (OAS1/2, IFIT1–3, RSAD2, MX1, TRIM14, ISG15) in HCV-infected hepatoma cells and mature iHLCs. The gene discussed is ISG15; the disease is hepatocellular carcinoma.