PRKN and Parkinson disease: Mutations in three genes, SNCA (best known as α-synuclein), LRRK2 (Leucine-rich repeat kinase 2), and VPS35 (Vacuolar protein sorting-associated protein 35), are known to cause a dominant form of PD, whereas mutations in PARK2 (parkin RBR E3 ubiquitin protein ligase, best known as Parkin), PINK1 (PTEN-induced putative kinase 1), and PARK7 (Parkinsonism associated deglycase, best known as DJ-1) cause recessive-inherited forms of the disease2.