3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo-liumbromide (MTT) assay results suggested that upregulation of WBP2 enhanced cell proliferation of glioma cells (Fig. 2a–d), while depletion of WBP2 inhibited cell proliferation. Here, WBP2 is linked to central nervous system cancer.