KMT2A and leukemia: It was later shown to be essential for the formation of a tripartite complex of MLL (mixed lineage leukaemia; HGNC nomenclature KMT2A) protein, menin (multiple endocrine neoplasia type 1; MEN-1) protein and LEDGF that is implicated in MLL (Cermáková et al., 2014 ▸).