Shikonin potently suppressed PC-3 and DU145 cell metastasis in a dose-dependent manner (0.5–2 μΜ) and inhibited the migration and invasion of the two aggressive prostate cancer cell lines by reducing MMP-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways [93]. Here, AKT1 is linked to Familial prostate cancer.