Gain-of-function mutations in the KCNQ1 gene have also been related to SQTS, inducing an increase in IKs either by accelerating the activation kinetics of KV7.1 [70] or by decreasing its inactivation due to an impaired regulation of minK, the β1-subunit of voltage-dependent K+ channels [71]. Here, KCNQ1 is linked to Familial short QT syndrome.