RYR2 and catecholaminergic polymorphic ventricular tachycardia: According to the 2015 European Society of Cardiology guidelines, CPVT can be currently diagnosed (class I recommendation): (1) in the presence of a structurally normal heart, normal ECG, and exercise- or emotion-induced bidirectional or polymorphic ventricular tachycardia; (2) in patients who are carriers of a pathogenic mutation in RYR2 or CASQ2 genes [13].