With the advent of next-generation sequencing (NSG)-based diagnostics, more than 20 different ALK fusion partners genes have been described in other type of cancer (i.e., colorectal cancer, breast cancer, esophageal cancer, ovarian cancer, renal cell cancer, anaplastic thyroid carcinoma, and diffuse large B-cell lymphoma) even though in low frequencies (Table 1). The gene discussed is ALK; the disease is cancer.