ALK and lung cancer: Some clinical trials are investigating the efficacy and safety of an ALK TKI combined with immunotherapy in lung cancer, namely, crizotinib with nivolumab or ipilimumab (NCT01998126) or pembrolizumab (NCT02511184); alectinib with atezolizumab (NCT02013219); ceritinib combined with nivolumab (NCT02393625) and lorlatinib with avelumab (NCT02584634).