Moreover, analyses of human tumor cells, specifically prostate cancer and melanoma cells, revealed that regulation of global H2A deubiquitination by MYSM1 may lead to an overall enhancement of proliferative gene signatures, including androgen-receptor (AR) regulated gene expression [14] and hepatocyte-growth factor (HGF)/c-Met regulated gene expression [25]. The gene discussed is AR; the disease is Familial prostate cancer.