This relationship between higher levels of AQP1 in MPM tissues and a better prognosis is quite surprising, as it appears to be in contrast to that reported in other tumors, including breast cancer, brain tumors, prostate adenocarcinoma, lung adenocarcinoma and carcinomas of the gastrointestinal tract, for which increased levels of AQP1 are associated with a poorer prognosis [12,31,32,33,34,35,36,37,38]. This evidence concerns the gene AQP1 and brain neoplasm.