PDE11A and Cushing syndrome due to macronodular adrenal hyperplasia: The PDE11A R307X mutation conferred a 7 mmHg higher SBP and a 4.6 mmHg higher DBP (β coefficients = 7.0 (1.8–12) for SBP corrected, p = 0.009 and 4.6 (1.8–7.4) for DBP corrected, p = 0.001) and was previously described as a loss-of-function mutation linked to familial hypertension and Cushing’s syndrome [42].