HOTTIP and neoplasm: The role of miRNAs in HOTTIP regulation has been further unraveled by Ge et al., who observed a negative correlation between HOTTIP and miR-192/204 in 48 tumor-normal paired liver samples and showed that HOTTIP expression can be regulated by miR-192 and miR-204 via the canonical Argonaute2 mediated interference (siRNA) [136].