However, cytochrome P450 2J6 (cyp2j6), adenylate cyclase type 6 (LOC100702460), insulin receptor-like (LOC102777679), insulin-like growth factor 1 receptor-like (igf-1r), cytosolic phospholipase A2 (pla2g4a), guanine nucleotide-binding protein G(s) subunit alpha (LOC100710082), and cytochrome P450 aromatase (cyp19a1a) were found to be significantly downregulated in IM compared with CF. The gene discussed is IGF1R; the disease is cystic fibrosis.