Thus, in this study, we suggest that the increase of the LB levels observed in monocytes of the IgM-negative group, despite not being associated with alterations in the plasma levels of eicosanoids or the mRNA levels of genes involved in eicosanoid-forming enzymes in leukocytes, is due to DENV infection and replication, since this increase was observed in the subpopulations of both positive and negative CD16 monocytes, both of which are permissive cells to viral infection and replication [35]. This evidence concerns the gene CD40LG and viral infectious disease.