Specific methylation patterns have been associated with variation in genes that are related to glioblastoma survival and treatment efficacy, including global hypermethylation resulting from isocitrate dehydrogenase (IDH) mutation [31,32] and inverted correlation between promoter methylation and protein expression of O6-methylguanine-DNA methyltransferase (MGMT) [33]. The gene discussed is MGMT; the disease is glioblastoma.