Although the role of TLR2 and TLR4 in malaria remain unclear [25,27,28,29,30], mice deficient in TLR9 were reported to be resistant to PbA-induced experimental cerebral malaria (ECM), suggesting a pathological role of TLR9 rather than a protective role during cerebral malaria [11]. Here, TLR9 is linked to cerebral malaria.