CREB1 and central nervous system cancer: For example, miR-9-CREB negative feedback minicircuitry plays a critical role in the determination of proliferation and migration in glioma cells [63,64]; miR-433-3p suppresses cell growth and enhances chemosensitivity by targeting CREB in human glioma [65]; miR-26a/Kruppel like factor 4 (KLF4) and cAMP responsive element binding protein CCAAT/enhancer binding protein (CREB-C/EBPβ) signaling pathways regulate survival of mycobacterium tuberculosis in macrophages [66].