Fluoxetine is a widely used antidepressant in treatment of mood and anxiety disorders via regulating miR-29 family and genes such as brain derived neurotrophic factor (BDNF), response regulator in two-component regulatory system with CreC (CREB), and HUS-associated diffuse adherence (HDACs) [46,47,48,49]. The gene discussed is CREB1; the disease is anxiety disorder.