In these tumors and in colon tumors not bearing mutations in the TGF-β1 signaling pathway, the cancer cells co-opt into their own service several TGF-β-initiated pathways that are not oncogenic in a normal cellular context, again turning TGF-β into an unwitting pro-tumorigenic agent [81,92]. The gene discussed is TGFB1; the disease is colonic neoplasm.