TGFB1 and neoplasm: In the present review, among the molecular agents promoting the generation of CAFs, we have singled out TGF-β1, a master cytokine overexpressed by both tumor cells and stromal CAFs essential for the fibroblast-to-myofibroblast trans-differentiation and, consequently, for the shaping of the CAF phenotype [16,17,18,19].