Furthermore, intratumoral and cell media concentrations of hIL-12 protein were also statistically significantly increased in B16F10 melanoma cells by a factor of 800–1000 and in tumors by a factor of 10,000–12,000, 3 days after p21-hIL-12-ORT GET (Figure 2b,c). This evidence concerns the gene CDKN1A and melanoma.