Mutations and deletions in the 11q chromosomal arm region that contains the H2A.X gene, as well as other important DNA damage response factors, like ATM, happen frequently in cancers such as sporadic breast cancer [157], neuroblastoma [158], head and neck squamous cell carcinomas [160] and in hematopoietic malignancies like chronic lymphocytic leukaemia [163,164]. This evidence concerns the gene H2AX and cancer.