However, the small size of the cohort examined here and the fact that disease designation was based solely on clinical criteria now necessitate a study with a larger number of subjects who preferably have disease designation validated, either by autopsy or by measurements of accepted CSF AD biomarkers, i.e., Aβ42, mid-region tau, and p181 tau [47,81,82]. The gene discussed is MAPT; the disease is Alzheimer disease.