According to the definitions extrapolated from the BEST resource they classify as diagnostic, prognostic and predictive biomarkers, and so are more recently tested biomarkers that could be isolated from the serum of cancer patients, such as: VEGFR-2, EGFRvIII, PGAM1, IL2, PDGFR, MMPs, BRAF, STAT3, PTEN, TERT, AKT, NF2, and BCL2 [15,16,17,18,19,20,21,22,23,24]. The gene discussed is IL2; the disease is cancer.