In mice with chemically-induced atopic dermatitis, potato extract alleviated the exacerbation of skin lesions by suppressing total serum level of IgE and maintaining T helper 1 (Th1; interferon-γ, and IL-12) and Th2 cytokines (IL-4 and IL-13) balance [37]. The gene discussed is IGHE; the disease is atopic eczema.