MYLK and aneurysm: Mutations in genes encoding proteins of the contractile/signaling modules of smooth muscle cells, including ACTA2 (smooth muscle α-actin), MYH11 (smooth muscle myosin heavy chain), MYLK (myosin light chain kinase), and PRKG1 (PKG type-1) [1–4], predispose to thoracic aortic disease with aneurysms and acute ascending aortic dissections in humans [5].